Pienkos E J, Meisner L F
Division of Urology, Carle Clinic, Urbana, Illinois.
J Urol. 1991 Jan;145(1):148-50.
We report a case of adenocarcinoma of the prostate in a 41-year-old man with 47XXY karyotype (Klinefelter's syndrome) and chronic lymphocytic leukemia. The increased incidence of malignancy in individuals with Klinefelter's syndrome has been well documented for certain neoplasms. Adenocarcinoma of the prostate has not been reported previously in a patient with Klinefelter's syndrome and a 47XXY karyotype. Absence of mosaicism was confirmed by peripheral lymphocyte, skin fibroblast, bone marrow cell and spleen stroma fibroblast cultures. Chronic lymphocyte leukemia, especially the T-cell cytotoxic/suppressive variant, may additionally add to an immunological deficit. Since carcinoma of the prostate, Klinefelter's syndrome and chronic lymphocytic leukemia are common, the lack of a previous report is interesting. Etiological aspects are discussed.
我们报告了一例41岁男性前列腺腺癌病例，该患者具有47XXY核型（克兰费尔特综合征）并患有慢性淋巴细胞白血病。克兰费尔特综合征患者某些肿瘤的恶性肿瘤发病率增加已得到充分证实。此前尚未有关于克兰费尔特综合征且核型为47XXY的患者发生前列腺腺癌的报道。通过外周淋巴细胞、皮肤成纤维细胞、骨髓细胞和脾基质成纤维细胞培养证实不存在嵌合体现象。慢性淋巴细胞白血病，尤其是T细胞细胞毒性/抑制性变体，可能会进一步加重免疫缺陷。由于前列腺癌、克兰费尔特综合征和慢性淋巴细胞白血病都很常见，此前缺乏相关报道很有意思。本文讨论了病因学方面的问题。
