Department of Pediatrics, Juntendo University School of Medicine, 2-1-1 Hongo, Bunkyo, Tokyo, 113-8421 Japan.
Early Hum Dev. 2009 Dec;85(12):733-5. doi: 10.1016/j.earlhumdev.2009.09.006. Epub 2009 Oct 17.
To determine whether the intrauterine environment affects lipid metabolism, we measured the fatty acid composition of the brain in rats with intrauterine growth retardation (IUGR) induced by synthetic thromboxane A2 (STA2). Additionally, we evaluated the effect of maternal docosahexaenoic acid (DHA)-enriched diet.
Two experimental diets were provided: soy bean oil and DHA-enriched diets. Maternal rats were divided randomly into three groups, STA2-/Soy (Sham), STA2+/Soy (IUGR), and STA2+/DHA (DHA) groups. The Sham and IUGR groups were fed the soy diet, and the DHA group received the DHA-enriched diet from embryonic day 7 until delivery. On postnatal days 1 and 7, the pups were weighed and their brains were removed for lipid analysis.
The body weight of the IUGR and DHA groups was significantly less than that of the Sham group both on the postnatal days 1 and 7, whereas it was not significantly different between the IUGR and DHA groups either on postnatal day 1 or day 7. There was no significant difference in the percentage of DHA between the Sham and IUGR groups either on postnatal day 1 or 7. On the other hand, the percentage of DHA was higher in the DHA group than in the IUGR group both on the postnatal days 1 and 7.
The fatty acid composition in the brain was not altered in the STA2-induced IUGR rat model. Increased DHA percentage was observed in the maternal DHA-enriched diet group, although no beneficial effect on body weight gain was observed.
为了确定宫内环境是否影响脂代谢，我们测量了由合成血栓烷 A2（STA2）诱导的宫内生长迟缓（IUGR）大鼠的大脑脂肪酸组成，并评估了母体二十二碳六烯酸（DHA）富集饮食的影响。
提供了两种实验饮食：大豆油和 DHA 富集饮食。将母鼠随机分为三组：STA2-/Soy（Sham）、STA2+/Soy（IUGR）和 STA2+/DHA（DHA）组。Sham 和 IUGR 组喂大豆饮食，DHA 组从胚胎第 7 天到分娩时接受 DHA 富集饮食。在产后第 1 天和第 7 天，称重幼鼠并取出其大脑进行脂质分析。
IUGR 和 DHA 组的体重在产后第 1 天和第 7 天均显著低于 Sham 组，而在产后第 1 天和第 7 天，IUGR 和 DHA 组之间的体重差异无统计学意义。在产后第 1 天和第 7 天，Sham 和 IUGR 组之间的 DHA 百分比也没有显著差异。另一方面，DHA 组的 DHA 百分比在产后第 1 天和第 7 天均高于 IUGR 组。
在 STA2 诱导的 IUGR 大鼠模型中，大脑的脂肪酸组成没有改变。尽管在母体 DHA 富集饮食组中观察到 DHA 百分比增加，但体重增加没有受益。
