Yu Ji Hee, Choi Kee Don, Koh Young Wha, Choi Won Jung, Song Ho June, Lee Gin Hyug, Jung Hwoon Yong, Kim Jin Ho
Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
Korean J Gastroenterol. 2009 Sep;54(3):174-9. doi: 10.4166/kjg.2009.54.3.174.
Extranodal NK/T-cell lymphoma is a recently recognized distinct entity within the World Health Organization classification of lymphoid tumors. It is relatively prevalent in Asian and South American populations. It most commonly occurs in the nasal or paranasal areas and less frequently in the skin, the soft tissue, and the gastrointestinal tract. Among these, extranodal NK/T-cell lymphoma of the gastrointestinal tract has shown an aggressive clinical course. We report a case of CD56+ extranodal NK/T-cell lymphoma presenting as a duodenal ulcer bleeding. A 62-year-old male patient presented with melena and abdominal pain. Endoscopic examination of the upper gastrointestinal tract showed the duodenal ulcer covered by blood clot. Pathologic examination revealed the diffuse infiltration of atypical lymphocytes with an angiocentric growth pattern, which was positive for CD3, CD56, and granzyme. The patient showed rapid deteriorating clinical course and died on day 14 after admission. Thus, we report this case with the review of literatures.
结外NK/T细胞淋巴瘤是世界卫生组织淋巴肿瘤分类中最近才被认识到的一种独特类型。它在亚洲和南美人群中相对常见。它最常发生于鼻腔或鼻旁区域，较少见于皮肤、软组织和胃肠道。其中，胃肠道结外NK/T细胞淋巴瘤已显示出侵袭性的临床病程。我们报告1例表现为十二指肠溃疡出血的CD56⁺结外NK/T细胞淋巴瘤病例。一名62岁男性患者出现黑便和腹痛。上消化道内镜检查显示十二指肠溃疡被血凝块覆盖。病理检查显示非典型淋巴细胞呈弥漫性浸润，具有血管中心性生长模式，CD3、CD56和颗粒酶呈阳性。该患者临床病程迅速恶化，入院后第14天死亡。因此，我们报告此病例并复习相关文献。
