Pongsatha Saipin, Ekmahachai Molrudee, Chaovisitsaree Somsak, Suntornlimsiri Nuchanart, Morakote Nuntana
Department of Obstetrics and Gynecology, Faculty of Medicine, Chiang Mai University, Thailand.
J Med Assoc Thai. 2009 Oct;92(10):1263-7.
To compare the effect of long-term use of depot medroxyprogesterone acetate (DMPA) on bone mineral density (BMD) in Thai women compared to the control.
A cross sectional study was conducted on Thai women of reproductive age who used DMPA (50 subjects) for contraception for at least 2 years and non-hormonal users (50 subjects). BMD was measured at the lumbar spine, femur and distal radius, and ulna.
There was significantly lower BMD at the lumbar spines in the DMPA group but there was no significant difference in BMD between groups at the femur distal radius, and ulna.
Long-term use of DMPA has a negative impact on lumbar spine BMD.
比较长期使用醋酸甲羟孕酮长效注射剂（DMPA）对泰国女性骨密度（BMD）的影响，并与对照组进行对比。
对使用DMPA（50名受试者）避孕至少2年的育龄泰国女性和非激素使用者（50名受试者）进行了一项横断面研究。在腰椎、股骨、桡骨远端和尺骨测量骨密度。
DMPA组腰椎的骨密度显著较低，但在股骨、桡骨远端和尺骨处，两组之间的骨密度没有显著差异。
长期使用DMPA对腰椎骨密度有负面影响。
