Treatment of acute organophosphate poisoning.

The biochemistry and pharmacology of poisoning by organophosphorus esters and carbamates are outlined and methods of diagnosis and treatment are discussed. Treatment consists of reduction of exposure by decontamination, induction of vomiting or gastric lavage; pharmacological treatment with atropine and oximes (pralidoxime and obidoxime); and supportive treatment with artificial respiration and centrally acting drugs such as diazepam. The sequence of treatment depends solely on the severity of poisoning.