Chlup Rudolf, Zapletalova Jana, Peterson Karolina, Poljakova Iveta, Lenhartova Eva, Tancred Adam, Perera Russel, Smital Jan
Department of Physiology, Palacky University, Olomouc, Czech Republic.
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2009 Sep;153(3):205-9. doi: 10.5507/bp.2009.034.
The purpose of this prospective controlled trial was to assess the efficacy of three commercially available glucose products, (1) buccal glucose spray, (2) liquid sugars, and (3) dextrose tablet, on the evolution of plasma glucose concentration (PG).
Sixteen healthy volunteers aged 21.8 +/- 0.78 y (mean +/- SE), BMI 23.5 +/- 0.84 kg/m(2), tested their PG over the course of 3 sets of 4 sessions (S) each: S(0)-control fasting, S(1)-buccal administration of 10 glucose spray-doses (0.84 g of glucose) without swallowing; S(2-) consumption of 1 sachet (13 ml) of liquid sugar (ca. 5.2 g glucose, 5.2 g fructose, 5.2 g sucrose); S(3-) consumption of one dextrose tablet (6 g). PG was tested in finger-prick capillary blood using a personal glucometer Linus at the start, and at 5, 10, 15, 20 and 30 min. The means of 3 respective sessions for each of the 16 subjects were analyzed.
The Wilcoxon signed rank test revealed no significant differences between changes in the mean PG at the start vs. 5-minute interval either in control, or any intervention sessions. Analysis of regression coefficients after 30 min compared to the control session, demonstrated an increase in PG with the sachet of liquid sugars (0.068 mmol/l/min, p = 0.001) which was greater than a single dextrose tablet (0.052 mmol/l/min, p = 0.002), but no significant PG increase was found after buccal glucose spray.
Liquid sugars or dextrose tablets, but not the buccal glucose spray, are effective means to increase PG within 10 minutes after ingestion.
本前瞻性对照试验旨在评估三种市售葡萄糖产品，即（1）口腔葡萄糖喷雾、（2）液体糖和（3）葡萄糖片，对血浆葡萄糖浓度（PG）变化的疗效。
16名年龄为21.8±0.78岁（均值±标准误）、体重指数为23.5±0.84kg/m²的健康志愿者，在3组每组4次试验过程中检测其PG：S(0)——空腹对照；S(1)——口腔给予10剂葡萄糖喷雾（0.84g葡萄糖）且不吞咽；S(2)——食用1袋（13ml）液体糖（约5.2g葡萄糖、5.2g果糖、5.2g蔗糖）；S(3)——食用1片葡萄糖片（6g）。在开始时以及5、10、15、20和30分钟时，使用个人血糖仪Linus检测指尖毛细血管血中的PG。对16名受试者各自3次试验的均值进行分析。
Wilcoxon符号秩检验显示，在对照或任何干预试验中，开始时与5分钟间隔时平均PG的变化之间均无显著差异。与对照试验相比，30分钟后回归系数分析表明，液体糖包可使PG升高（0.068mmol/l/分钟，p = 0.001），高于单片葡萄糖片（0.052mmol/l/分钟，p = 0.002），但口腔葡萄糖喷雾后未发现PG有显著升高。
液体糖或葡萄糖片是摄入后10分钟内升高PG的有效手段，但口腔葡萄糖喷雾并非如此。
