美金刚：治疗阿尔茨海默病和其他痴呆症的安全性和疗效研究综述。
Memantine: a review of studies into its safety and efficacy in treating Alzheimer's disease and other dementias.
机构信息
Department of Neurology and Psychiatry, Saint Louis University School of Medicine, St. Louis, MO, USA.
出版信息
Clin Interv Aging. 2009;4:367-77. doi: 10.2147/cia.s6666. Epub 2009 Oct 12.
Abstract
Memantine is an uncompetitive N-methyl-D-aspartate receptor antagonist with moderate affinity. Its mechanism of action is neuroprotective and potentially therapeutic in several neuropsychiatric diseases. It has been approved by the FDA for the treatment of moderate to severe Alzheimer's disease (AD) either as a monotherapy or in combination with cholinesterase inhibitors. This review covers key studies of memantine's safety and efficacy in treating moderate to severe AD. It also covers current research into other dementias including but not exclusively mild AD and vascular dementia. Other studies on the efficacy of memantine for other neuropsychiatric diseases are discussed. Memantine is a safe and effective drug that merits further research on several topics. Clinicians should be aware of new studies and potential uses of memantine because of its safety and efficacy.
摘要
盐酸美金刚是一种具有中等亲和力的非竞争性 N-甲基-D-天冬氨酸受体拮抗剂。其作用机制具有神经保护作用，在几种神经精神疾病中具有潜在的治疗作用。它已被 FDA 批准用于治疗中重度阿尔茨海默病（AD），可作为单药治疗或与胆碱酯酶抑制剂联合使用。这篇综述涵盖了盐酸美金刚治疗中重度 AD 的安全性和疗效的关键研究。它还涵盖了当前对其他痴呆症的研究，包括但不限于轻度 AD 和血管性痴呆症。还讨论了其他关于美金刚治疗其他神经精神疾病的疗效的研究。盐酸美金刚是一种安全有效的药物，值得在几个方面进行进一步研究。由于其安全性和疗效，临床医生应该了解美金刚的新研究和潜在用途。
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