Drug Target Discovery and Development Division (DTDD), Central Drug Research Institute, CDRI, Chhattar Manzil, Lucknow, UP, India.
Mol Cell Biochem. 2010 Apr;337(1-2):111-8. doi: 10.1007/s11010-009-0290-3. Epub 2009 Oct 23.
CCAAT/enhancer binding proteins (C/EBPs) are a group of transcription factors which have been implicated in cellular proliferation, terminal differentiation, and apoptosis in a variety of tissues including mammary gland. Owing to its role in various cellular functions, inactivation of C/EBP proteins is central to the pathogenesis of many disorders. Recent reports suggest that expression as well as function of C/EBP proteins is deregulated in breast tumors. Although, role of C/EBPs in growth arrest in mammary tissues has been studied in much detail; their role in apoptosis is relatively less explored. In the present study, we have assessed if breast tumors evade apoptosis and grow faster by down regulating and inhibiting the C/EBP proteins, C/EBPalpha in particular. Our data shows that ectopic expression of human C/EBPs in breast tumor cells inhibits proliferation and induces apoptosis which is likely to be associated with caspase dependent pathway.
CCAAT/增强子结合蛋白（C/EBP）是一组转录因子，其在多种组织（包括乳腺）中的细胞增殖、终末分化和细胞凋亡中发挥作用。由于其在各种细胞功能中的作用，C/EBP 蛋白的失活是许多疾病发病机制的核心。最近的报告表明，C/EBP 蛋白在乳腺肿瘤中的表达和功能失调。尽管 C/EBP 在乳腺组织中的生长抑制作用已被深入研究，但它们在细胞凋亡中的作用相对较少被探索。在本研究中，我们评估了乳腺肿瘤是否通过下调和抑制 C/EBP 蛋白，特别是 C/EBPalpha，来逃避细胞凋亡并更快地生长。我们的数据表明，在乳腺肿瘤细胞中异位表达人 C/EBP 会抑制增殖并诱导细胞凋亡，这可能与 caspase 依赖性途径有关。
