Shetty Anjali, Marcum Catherine B, Glass L Frank, Carter John D
University of South Florida College of Medicine,Tampa, FL 33612, USA.
J Drugs Dermatol. 2009 Oct;8(10):940-3.
Pemphigus vulgaris is an autoimmune disease characterized by intraepidermal blister formation. The treatment of pemphigus vulgaris is generally regarded as difficult. Corticosteroids, the drug class of first choice, often must be combined with steroid-sparing agents to prevent hazardous, long-term side effects. The authors describe four patients with severe pemphigus vulgaris who were treated with the tumor necrosis factor (TNF)-alpha antagonist, etanercept, twice weekly. In all four cases, the addition of etanercept produced dramatic clinical improvement and facilitated the reduction of corticosteroids necessary to maintain symptom control. Thus, etanercept may be an effective therapeutic agent for pemphigus vulgaris and should be considered as an alternative treatment option for patients presenting with recalcitrant disease.
寻常型天疱疮是一种以表皮内水疱形成为特征的自身免疫性疾病。寻常型天疱疮的治疗通常被认为具有挑战性。皮质类固醇是首选药物类别，常常必须与激素节省剂联合使用以预防有害的长期副作用。作者描述了4例严重寻常型天疱疮患者，他们接受了肿瘤坏死因子（TNF）-α拮抗剂依那西普治疗，每周两次。在所有4例患者中，加用依那西普均产生了显著的临床改善，并有助于减少维持症状控制所需的皮质类固醇用量。因此，依那西普可能是治疗寻常型天疱疮的一种有效治疗药物，对于患有顽固性疾病的患者应考虑将其作为一种替代治疗选择。
