Lan Dong, Zhang Hai-Yan, Pang Bao-Sen
Department of Dermatology, Chaoyang Hospital (Jing-xi Camtus) Affiliated to Capital Medical University, Beijing.
Zhongguo Zhong Xi Yi Jie He Za Zhi. 2009 Jul;29(7):611-3.
To explore the mechanism of Chinese medicinal therapy for nourishing blood and softening Gan in treating senile pruritus through observing the impact of Guishen Zhiyang Recipe (GZR) on serum levels of stem cell factor (SCF) and dynorphin (DYN) in patients suffered from the disease of blood-deficiency and Gan-hyperactive syndrome type (BDGH).
Sixty patients with senile pruritus were equally randomized into two groups, the patients in the treated group (33 cases) were treated by GZR, and those in the control group (28 cases) were treated by Fuyang Granule, all for 8 weeks. Changes of symptoms and skin lesions as well as blood levels of SCF and DYN were observed before and after treatment.
Three patients were rejected from the treated group. Twenty patients in the treated group were cured after treatment, the cure rate being 66.7%, which was significantly higher than that in the control group (10 patients, 35.7%, P < 0.05). Levels of SCF and DYN in the treated group significantly lowered after treatment (all P < 0.01), and were lower than those in the control group (P < 0.05 and P < 0.01, respectively).
GZR shows favorite effect in treating senile pruritus of BDGH type and it may be achieved by regulating SCF and DYN levels to improve the pruritus associated inflammatory media.
通过观察归参止痒方（GZR）对血虚肝旺证（BDGH）型老年瘙痒症患者血清干细胞因子（SCF）和强啡肽（DYN）水平的影响，探讨养血柔肝法治疗老年瘙痒症的机制。
将60例老年瘙痒症患者随机分为两组，治疗组（33例）采用归参止痒方治疗，对照组（28例）采用肤痒颗粒治疗，疗程均为8周。观察两组治疗前后症状、皮损变化及SCF、DYN水平变化。
治疗组脱落3例。治疗组20例治愈，治愈率为66.7%，明显高于对照组（10例，35.7%，P<0.05）。治疗组治疗后SCF、DYN水平明显降低（均P<0.01），且低于对照组（分别为P<0.05和P<0.01）。
归参止痒方治疗BDGH型老年瘙痒症疗效显著，其机制可能是通过调节SCF和DYN水平，改善瘙痒相关炎性介质实现的。
