Kushner M J, Zanette E M, Bastianello S, Mancini G, Sacchetti M L, Carolei A, Bozzao L
Department of Neurology, University of Pennsylvania, Philadelphia.
Neurology. 1991 Jan;41(1):109-13. doi: 10.1212/wnl.41.1.109.
We studied cerebrovascular anatomy using intra-arterial digital angiography, and blood flow velocity in the middle cerebral artery (MCA) using transcranial Doppler (TCD) ultrasonography in 42 patients with acute hemispheric ischemic brain infarction. We compared angiography with TCD and the clinical findings within 6 hours of the onset of symptoms. The location and extent of the chronic ischemic brain damage was assessed by CT performed 1 to 3 months after the ictus. Abnormal TCD, as manifested by either an unobtainable MCA flow signal or a significantly depressed MCA flow velocity, was highly associated with proximal MCA occlusions demonstrated by angiography. Abnormal TCD predicted both larger chronic CT lesions and more extensive ischemic change within the MCA territory. These data demonstrate that early TCD conveys useful information concerning cerebral tissue prognosis following hemispheric ischemia.
我们使用动脉内数字血管造影术研究了42例急性半球缺血性脑梗死患者的脑血管解剖结构，并使用经颅多普勒（TCD）超声检查法研究了大脑中动脉（MCA）的血流速度。我们在症状发作6小时内将血管造影与TCD以及临床发现进行了比较。通过发作后1至3个月进行的CT评估慢性缺血性脑损伤的位置和范围。TCD异常表现为无法获得MCA血流信号或MCA血流速度明显降低，这与血管造影显示的近端MCA闭塞高度相关。TCD异常预示着更大的慢性CT病变以及MCA区域内更广泛的缺血性改变。这些数据表明，早期TCD可传达有关半球缺血后脑组织预后的有用信息。
