Aberg Karolina, Dai Feng, Viali Satupaitea, Tuitele John, Sun Guangyun, Indugula Subba R, Deka Ranjan, Weeks Daniel E, McGarvey Stephen T
Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, 130 Desoto St, Pittsburgh, PA 15261, USA.
BMC Med Genet. 2009 Oct 23;10:107. doi: 10.1186/1471-2350-10-107.
High blood pressure or hypertension is a major risk factor involved in the development of cardiovascular diseases. We conducted genome-wide variance component linkage analyses to search for loci influencing five blood pressure related traits including the quantitative traits systolic blood pressure (SBP), diastolic blood pressure (DBP) and pulse pressure (PP), the dichotomous trait hypertension (HT) and the bivariate quantitative trait SBP-DBP in families residing in American Samoa and Samoa, as well as in the combined sample from the two polities. We adjusted the traits for a number of environmental covariates such as smoking, alcohol consumption, physical activity and material life style.
We found suggestive univariate linkage for SBP on chromosome 2q35-q37 (LOD 2.4) and for PP on chromosome 22q13 (LOD 2.2), two chromosomal regions that recently have been associated with SBP and PP, respectively.
We have detected additional evidence for a recently reported locus associated with SBP on chromosome 2q and a susceptibility locus for PP on chromosome 22q. However, differences observed between the results from our three partly overlapping genetically homogenous study samples from the Samoan islands suggest that additional studies should be performed in order to verify these results.
高血压是心血管疾病发展过程中的一个主要风险因素。我们进行了全基因组方差成分连锁分析，以寻找影响五个血压相关性状的基因座，这些性状包括定量性状收缩压（SBP）、舒张压（DBP）和脉压（PP），二分性状高血压（HT）以及美属萨摩亚和萨摩亚群岛居民家庭中的双变量定量性状SBP-DBP，以及来自这两个政体的合并样本。我们针对一些环境协变量对这些性状进行了调整，如吸烟、饮酒、身体活动和物质生活方式。
我们在2q35-q37染色体上发现了SBP的提示性单变量连锁（LOD 2.4），在22q13染色体上发现了PP的提示性单变量连锁（LOD 2.2），这两个染色体区域最近分别与SBP和PP相关。
我们已经检测到了与2q染色体上最近报道的与SBP相关的基因座以及22q染色体上PP的易感基因座相关的更多证据。然而，我们来自萨摩亚群岛的三个部分重叠的基因同质研究样本的结果之间观察到的差异表明，应该进行更多研究以验证这些结果。
