Falasca Marco, Maffucci Tania
Queen Mary University of London, Barts and The London School of Medicine and Dentistry, Blizard Institute of Cell and Molecular Science, Centre for Diabetes, Inositide Signalling Group, 4 Newark Street, London E1 2AT, UK.
Biochim Biophys Acta. 2009 Dec;1793(12):1795-803. doi: 10.1016/j.bbamcr.2009.10.003. Epub 2009 Oct 21.
A generally accepted view considers phosphatidylinositol 3-monophosphate (PtdIns3P) as a lipid confined to the endosomal compartment where it regulates trafficking pathways and is produced constitutively and exclusively by class III phosphoinositide 3-kinase (PI3K). Recent evidence suggests that this phosphoinositide has a more complex role as a second messenger involved in different physiological and pathological events and that specific intracellular localization of kinases and/or phosphatases is critical for PtdIns3P synthesis and PtdIns3P-dependent intracellular functions. Here, we review the current knowledge of the regulation and function of PtdIns3P and discuss how the view of PtdIns3P changed in the last few years.
一种普遍接受的观点认为，磷脂酰肌醇3-单磷酸（PtdIns3P）是一种局限于内体区室的脂质，它在其中调节运输途径，并且由III类磷酸肌醇3-激酶（PI3K）组成性地且唯一地产生。最近的证据表明，这种磷酸肌醇作为参与不同生理和病理事件的第二信使具有更复杂的作用，并且激酶和/或磷酸酶的特定细胞内定位对于PtdIns3P的合成和PtdIns3P依赖性细胞内功能至关重要。在这里，我们综述了关于PtdIns3P调节和功能的当前知识，并讨论了PtdIns3P的观点在过去几年中是如何变化的。
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