关于梳齿、切口与肿瘤：表观遗传学与信号传导相遇
About combs, notches, and tumors: epigenetics meets signaling.
作者信息
Merdes Gunter, Paro Renato
机构信息
Department of Biosystems Sciences and Engineering, ETH Zurich, Mattenstrasse 26, 4058 Basel, Switzerland.
出版信息
Dev Cell. 2009 Oct;17(4):440-2. doi: 10.1016/j.devcel.2009.10.001.
PMID:19853558
Abstract
The identities of cells, determined by differential gene expression, are heritably maintained by the antagonistic functions of Polycomb group (PcG) and Trithorax group proteins. Two recent papers shed new light on tumor suppressive functions of PcG by reporting direct silencing of the Notch and JAK/STAT signaling pathways in Drosophila melanogaster.
摘要
细胞的身份由差异基因表达决定，并通过多梳蛋白家族（PcG）和三胸蛋白家族蛋白的拮抗作用得以遗传维持。最近的两篇论文通过报道果蝇中Notch和JAK/STAT信号通路的直接沉默，揭示了PcG的肿瘤抑制功能。
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