在吉兰-巴雷综合征患者中，γ干扰素将外周CD4(+)CD25(-) T细胞转化为CD4(+)CD25(+)调节性T细胞。
Conversion of peripheral CD4(+)CD25(-) T cells to CD4(+)CD25(+) regulatory T cells by IFN-gamma in patients with Guillain-Barré syndrome.
作者信息
Huang Shuo, Li Lei, Liang Songlan, Wang Weizhi
机构信息
Department of Neurology, the Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, 150086, PR China.
出版信息
J Neuroimmunol. 2009 Dec 10;217(1-2):80-4. doi: 10.1016/j.jneuroim.2009.10.001. Epub 2009 Oct 24.
CD4(+)CD25(-) T cells from 25 Guillain-Barré syndrome (GBS) patients were stimulated by IFN-gamma to generate the induced CD4(+)CD25(+) regulatory T cells (iTregs). Then, their phenotypical and functional characterizations were analyzed. Results show that iTregs can be generated from CD4(+)CD25(-) T cells in GBS patients by IFN-gamma in the presence of activating anti-CD3 and anti-CD28 antibodies in vitro. When CD4(+)CD25(-) T cells are stimulated by 40ng/ml IFN-gamma for 3days, the ratio of conversion is the highest under this condition and iTregs are similar to naturally occurring CD4(+)CD25(+) regulatory T cells of healthy donors phenotypically and functionally.
来自25例吉兰-巴雷综合征（GBS）患者的CD4(+)CD25(-) T细胞用γ干扰素刺激以产生诱导性CD4(+)CD25(+)调节性T细胞（iTregs）。然后，分析它们的表型和功能特征。结果表明，在体外存在激活的抗CD3和抗CD28抗体的情况下，GBS患者的CD4(+)CD25(-) T细胞可通过γ干扰素产生iTregs。当CD4(+)CD25(-) T细胞用40ng/mlγ干扰素刺激3天时，在此条件下转化率最高，且iTregs在表型和功能上与健康供体天然存在的CD4(+)CD25(+)调节性T细胞相似。
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