KLE University, Nehru Nagar, Belgaum, Karnataka, India.
J Ethnopharmacol. 2010 Feb 3;127(2):565-7. doi: 10.1016/j.jep.2009.10.018. Epub 2009 Oct 23.
Cucumis trigonus Roxb. (Cucurbitaceae) fruit is used in the Indian traditional medicine for the treatment of diabetes. Based on a number of reports on the blood glucose level reduction and the other complications of diabetes associated with some Cucurbitaceae plants, the antidiabetic effect of Cucumis trigonus fruit was investigated.
To investigate the antidiabetic action of the aqueous extract of Cucumis trigonus fruits in the different models of rats.
The antidiabetic activity of aqueous extract of Cucumis trigonus fruit was evaluated by using normal and streptozotocin-induced-diabetic rats. The acute effect of aqueous extract was evaluated by administering 500 mg/kg p.o. to normoglycemic rats. In the chronic model, the aqueous extract was administered to normal and STZ-induced-diabetic rats at dose of 500 mg/kg p.o. per day for 21 days. Blood glucose levels and body weights were monitored at specific intervals and different biochemical parameters were also carried out.
The statistical data indicated the significant increase in the body weight, liver glycogen and serum insulin level and decrease in the blood glucose, glycosylated hemoglobin levels, total cholesterol and serum triglycerides. HDL cholesterol level was significantly increased when treated with the extract.
The aqueous fruit extract of Cucumis trigonus has had beneficial effects in reducing the elevated blood glucose level and lipid profile of STZ-induced-diabetic rats.
黄瓜（葫芦科）的果实被印度传统医学用于治疗糖尿病。基于一些关于血糖水平降低和一些葫芦科植物相关的糖尿病并发症的报道，研究了黄瓜果实的降血糖作用。
研究黄瓜果实水提物在不同大鼠模型中的降血糖作用。
采用正常和链脲佐菌素诱导的糖尿病大鼠评价黄瓜果实水提物的降血糖活性。通过给正常血糖大鼠口服 500mg/kg 来评价水提物的急性作用。在慢性模型中，水提物以 500mg/kg 每天口服的剂量给予正常和 STZ 诱导的糖尿病大鼠，持续 21 天。在特定时间间隔监测血糖水平和体重，并进行不同的生化参数检测。
统计数据表明，体重、肝糖原和血清胰岛素水平显著增加，血糖、糖化血红蛋白水平、总胆固醇和血清甘油三酯显著降低。当用提取物治疗时，高密度脂蛋白胆固醇水平显著升高。
黄瓜果实的水提物对降低 STZ 诱导的糖尿病大鼠的血糖水平和血脂谱有有益的影响。
