Boehnke M
Department of Biostatistics, University of Michigan School of Public Health, Ann Arbor 48109-2029.
Am J Hum Genet. 1991 Jan;48(1):22-5.
Given genetic marker data on unrelated individuals, maximum-likelihood allele-frequency estimates and their standard errors are easily calculated from sample proportions. When marker phenotypes are observed on relatives, this method cannot be used without either discarding a subset of the data or incorrectly assuming that all individuals are unrelated. Here, I describe a method for allele frequency estimation for data on relatives that is based on standard methods of pedigree analysis. This method makes use of all available marker information while correctly taking into account the dependence between relatives. I illustrate use of the method with family data for a VNTR polymorphism near the apolipoprotein B locus.
给定无关个体的遗传标记数据，通过样本比例可以轻松计算出最大似然等位基因频率估计值及其标准误差。当在亲属中观察到标记表型时，若不丢弃一部分数据或错误地假设所有个体均无亲缘关系，就无法使用此方法。在此，我描述一种基于系谱分析标准方法的亲属数据等位基因频率估计方法。该方法利用了所有可用的标记信息，同时正确考虑了亲属之间的相关性。我用载脂蛋白B基因座附近VNTR多态性的家系数据说明了该方法的应用。
