丙型肝炎患者干扰素治疗相关的持续性精神病：病例研究和文献回顾。
Prolonged psychosis associated with interferon therapy in a patient with hepatitis C: case study and literature review.
机构信息
Department of Psychiatry, Chang-Hua Christian Hospital, Changhua, Taiwan.
出版信息
Psychosomatics. 2009 Sep-Oct;50(5):538-42. doi: 10.1176/appi.psy.50.5.538.
BACKGROUND
Although rare, psychosis can emerge during interferon (IFN)-alpha therapy and persist after therapy is completed.
OBJECTIVE
The authors report the case of a 30-year-old man with hepatitis C infection treated with IFN-alpha and ribavirin who developed acute psychosis with persecutory delusions and auditory hallucinations, resulting in a suicide attempt.
METHOD
The patient was treated with amisulpride for 6 weeks and then with risperidone for 6 weeks.
RESULTS
There was no improvement in symptoms until the patient was treated with quetiapine; he then had a marked recovery from the psychotic symptoms. The duration of the psychosis was 28 weeks.
CONCLUSION
Hepatitis C can be successfully treated with IFN therapy, and the risk of IFN-induced psychosis is low, with psychotic symptoms resolving in most cases after completion of IFN therapy with or without antipsychotic treatment. In prolonged psychosis induced by IFN, quetiapine might also be of benefit.
背景
干扰素（IFN）-α治疗期间会罕见出现精神病，且在治疗结束后仍会持续存在。
目的
作者报告了一例 30 岁男性丙型肝炎感染者，接受 IFN-α和利巴韦林治疗后出现急性精神病，表现为被害妄想和幻听，导致自杀未遂。
方法
患者接受氨磺必利治疗 6 周，然后接受利培酮治疗 6 周。
结果
患者在接受喹硫平治疗前症状没有改善；然后他的精神病症状有了明显的缓解。精神病持续了 28 周。
结论
丙型肝炎可以通过 IFN 治疗成功治愈，IFN 引起的精神病风险较低，大多数情况下在 IFN 治疗结束后，无论是否使用抗精神病药物治疗，精神病症状都会得到缓解。在由 IFN 引起的长时间精神病中，喹硫平也可能有益。
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