新型 bla(TEM)-阳性、氨苄西林敏感的流感嗜血杆菌菌株。
Novel bla(TEM)-positive ampicillin-susceptible strains of Haemophilus influenzae.
机构信息
School of Human Life Sciences, University of Tasmania, Newnham Drive, Launceston, Tasmania 7250, Australia.
出版信息
J Infect Chemother. 2009 Oct;15(5):340-2. doi: 10.1007/s10156-009-0700-1. Epub 2009 Oct 24.
PMID:19856076
Abstract
Two ampicillin-susceptible strains of Haemophilus influenzae were found to carry blaTEM genes. In one strain ampicillin susceptibility was explained by poor expression of a functional TEM-1 enzyme from a putative weak promoter created by a mutation in the promoter region of the gene, and in the other by production of an inactive mutant TEM enzyme.
摘要
两种对氨苄西林敏感的流感嗜血杆菌菌株被发现携带 blaTEM 基因。在一个菌株中，氨苄西林的敏感性是由一个假定弱启动子中突变导致的功能 TEM-1 酶表达不良引起的，而在另一个菌株中则是由产生无活性突变 TEM 酶引起的。
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