Văduva Delia Berceanu, Muntean Delia, Lonescu G, Licker Monica, Văduva M Berceanu, Velimirovici Dana, Rădulescu Matilda, Dumitraşcu V, Crăciunescu Mihaela, Dugăeşescu Dorina, Horhat F, Piluţ C, Bădiţoiu Luminiţa, Moldovan Roxana
Universitatea de Medicină, şi Farmacie Victor Babeş Timişoara.
Bacteriol Virusol Parazitol Epidemiol. 2008 Apr-Jun;53(2):103-7.
The Acinetobacter species are ubiquitary germs isolated more and more frequently, Acinetobacter baumannii being currently considered the second strictly aerobic microorganism involved in the ethiology of severe nosocomial infections. Acinetobacter baumannii is usually encountered in surgery and intensive care units, especially in patients with depressed immunity, in which various locations are possible, the most frequvent being the respiratory tract infections, urinary tract infections and bacteriemia.
The study used 52 strains of Acinetobacter spp. isolated from 1131 biological samples (bronchial aspirat, urine, wound secretion, blood, pus, CFS) obtained from the patients of the Timisoara Country Hospital. Identification of germs was performed using the API (BioMerieux) system, and the antibiotics sensitivity testing was made by disk diffusion testing (Kirby-Bauer), with automatic reading and phenotyping through the Osiris Evolution (BioRad) system.
The study of resistance to beta-lactamines has pointed out the predominance of penicillinase and cephalosporinase producing strains, 55.77% of the tested ones being part of this phenotype. 90.38% of the strains were resistant to one or more aminoglycosides. Of the tested strains 76.93% were resistant to fluoroquinolones, 86.54% to trimethoprim-sulphamethoxazole, and only 21.15% to tethracycline.
Among the emerging pathogens involved in the nosocomial infections, Acinetobacter baumannii strains have become, in the past decades, a real health issue, due to the variety and seriousness of clinical symptoms. Through the constant increase of the cases number, and the difficulty of applying an effective treatment, the above-mentioned strains showed a multiple resistance to antibiotics.
不动杆菌属是一种无处不在的细菌，越来越频繁地被分离出来，鲍曼不动杆菌目前被认为是导致严重医院感染的第二大严格需氧微生物。鲍曼不动杆菌通常在外科手术和重症监护病房中出现，尤其是在免疫力低下的患者中，感染部位可能多种多样，最常见的是呼吸道感染、尿路感染和菌血症。
本研究使用了从蒂米什瓦拉乡村医院患者的1131份生物样本（支气管抽吸物、尿液、伤口分泌物、血液、脓液、脑脊液）中分离出的52株不动杆菌属菌株。使用API（生物梅里埃）系统进行细菌鉴定，并通过纸片扩散法（Kirby-Bauer）进行抗生素敏感性测试，通过Osiris Evolution（伯乐）系统进行自动读数和表型分析。
对β-内酰胺类抗生素耐药性的研究指出，产青霉素酶和头孢菌素酶的菌株占主导地位，55.77%的受试菌株属于该表型。90.38%的菌株对一种或多种氨基糖苷类抗生素耐药。受试菌株中76.93%对氟喹诺酮类耐药，86.54%对甲氧苄啶-磺胺甲恶唑耐药，仅21.15%对四环素耐药。
在引起医院感染的新兴病原体中，鲍曼不动杆菌菌株在过去几十年中已成为一个真正的健康问题，这是由于临床症状的多样性和严重性。由于病例数量不断增加，且难以实施有效的治疗，上述菌株对多种抗生素耐药。
