Division of Transplant Surgery, Department of Transplantation, Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL 32224, United States.
World J Gastroenterol. 2009 Oct 28;15(40):5010-3. doi: 10.3748/wjg.15.5010.
Hepatitis C is the most common indication for orthotopic liver transplantation in the United States. Unfortunately, hepatitis C recurs universally in the transplanted liver and is the major cause of decreased graft and patient survival. The combination therapy of interferon and ribavirin has been shown to be the most effective therapy for recurrent hepatitis C. However, pre- and post-transplant hypersplenism often precludes patients from receiving the antiviral therapy. Splenectomy and partial splenic embolization are the two invasive modalities that can correct the cytopenia associated with hypersplenism. In this report we review the two treatment options, their associated outcomes and complications.
丙型肝炎是美国进行原位肝移植最常见的适应证。不幸的是，丙型肝炎在移植肝脏中普遍复发，是导致移植物和患者存活率下降的主要原因。干扰素和利巴韦林联合治疗已被证明是治疗丙型肝炎复发最有效的方法。然而，移植前和移植后脾功能亢进常使患者无法接受抗病毒治疗。脾切除术和部分脾动脉栓塞术是两种可纠正脾功能亢进相关细胞减少症的有创治疗方法。在本报告中，我们回顾了这两种治疗选择及其相关的结果和并发症。
