利用级联反应高效实现了血根碱类生物碱（+）-erysotramidine 的全合成。

Efficient formal total synthesis of the erythrina alkaloid (+)-erysotramidine, using a domino process.

机构信息

Institute of Organic and Biomolecular Chemistry, Georg-August University Göttingen, Germany.

出版信息

Org Lett. 2009 Nov 19;11(22):5230-3. doi: 10.1021/ol901980u.

DOI:10.1021/ol901980u

PMID:19860384

Abstract

A domino process consisting of an amidation, spirocyclization, and formation of an iminium ion and electrophilic aromatic substitution of a phenylethylamine and a ketoester leads to the spirocyclic skeleton of (+)-erysotramidine, which can be further transformed into the natural alkaloid.

摘要

一个多米诺反应过程包括酰胺化、螺环化、亚胺离子形成和亲电芳香取代反应，涉及苯乙胺和酮酯，导致(+)-erysotramidine 的螺环骨架形成，该骨架可以进一步转化为天然生物碱。