用于选择性合成四环肉桂并[5,4,3-cde]肉桂啉的新型多米诺反应。

New domino reaction for the selective synthesis of tetracyclic cinnolino[5,4,3-cde]cinnolines.

作者信息

Jiang Bo, Hao Wen-Juan, Zhang Jin-Peng, Tu Shu-Jiang, Shi Feng

机构信息

School of Chemistry and Chemical Engineering, Xuzhou Normal University, Jiangsu, PR China.

出版信息

Org Biomol Chem. 2009 Mar 21;7(6):1171-5. doi: 10.1039/b817930a. Epub 2009 Jan 29.

DOI:10.1039/b817930a

PMID:19262937

Abstract

A new domino reaction for the highly selective synthesis of tetracyclic cinnolino[5,4,3-cde]cinnolines using steric control was described. In this reaction, the use of anthenes with aliphatic groups (R(1)) leads to cinnolino[5,4,3-cde]cinnolines whereas anthenes with aryl groups (R(1)) result in N-amino-1,8-dioxoacridines.

摘要

描述了一种利用空间控制高度选择性合成四环肉桂并[5,4,3-cde]肉桂啉的新多米诺反应。在该反应中，使用带有脂肪族基团（R(1)）的蒽会生成肉桂并[5,4,3-cde]肉桂啉，而带有芳基基团（R(1)）的蒽则会生成N-氨基-1,8-二氧吖啶。