Sehgal V N, Rege V L, Mascarenhas M F
Lepr India. 1977 Apr;49(2):221-8.
The term 'reactions' is applied in the present text, to describe the acute episodes, recognized with the different types of leprosy. The incidence of reactions was found to be 9.7% of 1053 cases examined. They were seen in all types of leprosy, but their frequency and severity was marked in lepromatous and borderline cases, and in majority of them, the age ranged from 20-40 years. The precipitating factor(s) could not be established in many; in some dapsone was incriminated, followed by bacterial infection and malnutrition. The exacerbations of the existing lesion(s) either alone or in combination with new lesions (E.N.L.) and E.N.L. lesions alone, were the presenting clinical features. The constitutional symptoms were observed largely in the types other than the tuberculoid. Foot drop and contractures of the fingers were the common sequels of the reactions. An attempt has been made to explain their mechanisms in the light of the recent literature.
在本文中，“反应”一词用于描述在不同类型麻风病中所识别出的急性发作情况。在所检查的1053例病例中，发现反应的发生率为9.7%。在所有类型的麻风病中均可见到反应，但在瘤型和界线类病例中其发生频率和严重程度更为明显，且其中大多数患者的年龄在20至40岁之间。许多病例无法确定诱发因素；在一些病例中，氨苯砜被认为是诱因，其次是细菌感染和营养不良。现有皮损的加重，无论是单独出现还是与新皮损（结节性红斑）同时出现，以及单独的结节性红斑皮损，均为主要临床特征。全身性症状主要见于除结核样型之外的其他类型。足下垂和手指挛缩是反应常见的后遗症。已根据近期文献对其发病机制进行了解释。
