Department of General Practice and Community Medicine, University of Oslo, Oslo, Norway.
Int J Tuberc Lung Dis. 2009 Nov;13(11):1399-404.
To assess an active case-finding strategy for the identification of smear-positive pulmonary tuberculosis (TB) in a rural district of Amhara Region, Ethiopia.
Study kebeles (smallest administrative units) were randomly selected in a cross-sectional study. House-to-house visits involving individuals aged >or=15 years in all households of the kebeles were conducted. The heads of households were asked to identify subjects with TB symptoms. Identified suspects were asked to provide three sputum samples for smear microscopy.
Among the 47,478 individuals living in households that were screened, 1006 TB suspects and 38 cases were detected. This resulted in 38 cases of smear-positive TB, i.e., 80 per 100,000 population, using cluster sampling. The ratio of active vs. passive case detection was 2.5:1, indicating 2.5 undetected TB cases in the community for every smear-positive TB case receiving treatment during the survey period. A higher proportion of female patients was detected by the survey.
The study revealed a very high proportion of undiagnosed TB. This indicates that the potential for a large infectious pool and significant transmission of TB in the community is high. The expansion of diagnostic facilities and the active involvement of health extension workers is necessary to expedite early detection, timely referral and treatment of TB.
评估在埃塞俄比亚阿姆哈拉地区的一个农村地区采用主动病例发现策略来发现涂阳肺结核(TB)病例。
采用横断面研究方法随机选择研究村。对所有村中的 15 岁及以上居民进行逐户家访。要求户主识别具有 TB 症状的个体。发现的疑似病例被要求提供三份痰样进行涂片显微镜检查。
在所筛查的 47478 名居民中,发现了 1006 例 TB 疑似病例和 38 例病例,经聚类抽样,结果显示涂阳 TB 为 38 例,即每 100000 人口 80 例。主动病例发现与被动病例发现的比例为 2.5:1,这表明在调查期间,每发现 1 例涂阳 TB 病例接受治疗,就有 2.5 例 TB 病例未被发现。该调查发现了更多的女性患者。
研究显示,未确诊的 TB 病例比例非常高。这表明社区中存在大量潜伏性感染源和 TB 传播的高风险。需要扩大诊断设施并积极调动卫生推广工作者,以加快早期发现、及时转诊和治疗 TB。