Henao F J, Daes J E, Dennis R J
Department of Surgery, Hospital Universitario San Ignacio, Pontificia Universidad Javeriana, Bogota, Colombia.
J Trauma. 1991 Jan;31(1):74-80. doi: 10.1097/00005373-199101000-00014.
The aim of this study was to identify factors associated with Multiple Organ Failure (MOF), and assess possible interactions between the risk factors identified as such. We studied 40 MOF cases and 120 controls, out of all the surgery and trauma patients who needed intensive care at our institution in a 24-month period. The univariate analyses showed that age, hypovolemic shock, massive volume administration (MVA), sepsis, and time of evolution before arriving to the hospital (TE) were significantly associated with MOF. Logistic regression analysis showed that neither age nor MVA were independently associated with MOF after adjusting for all of the other variables. Interactions seemed to be present between age, sepsis, and shock. We conclude that in our surgery and trauma ICU adult patient population, hypovolemic shock, sepsis, and TE are independent risk factors for MOF. The importance of the association between shock and sepsis is discussed, as well as the possible relevance of TE as a risk factor.
本研究的目的是确定与多器官功能衰竭（MOF）相关的因素，并评估所确定的风险因素之间可能存在的相互作用。在我们机构24个月期间所有需要重症监护的手术和创伤患者中，我们研究了40例MOF病例和120例对照。单因素分析表明，年龄、低血容量性休克、大量液体输注（MVA）、脓毒症以及入院前病程时间（TE）与MOF显著相关。逻辑回归分析表明，在对所有其他变量进行校正后，年龄和MVA均与MOF无独立相关性。年龄、脓毒症和休克之间似乎存在相互作用。我们得出结论，在我们的手术和创伤重症监护病房成年患者群体中，低血容量性休克、脓毒症和TE是MOF的独立危险因素。本文讨论了休克与脓毒症之间关联的重要性，以及TE作为危险因素的可能相关性。
