Department of Pharmaceutical Technology, Medical University of Gdansk, Gdansk, Poland.
J Pharm Sci. 2010 Feb;99(2):587-97. doi: 10.1002/jps.21963.
This review presents current applications of spray drying in pharmaceutical technology. The topics discussed include the obtention of excipients and cospray dried composites, methods for increasing the aqueous solubility and bioavailability of active substances, and modified release profiles from spray-dried particles. This review also describes the use of the spray drying technique in the context of biological therapies, such as the spray drying of proteins, inhalable powders, and viable organisms, and the modification of the physical properties of dry plant extracts.
本文综述了喷雾干燥技术在药物制剂领域的应用。讨论的主题包括辅料和共喷雾干燥复合物的制备、提高活性物质水溶性和生物利用度的方法,以及喷雾干燥颗粒的缓释特性。本文还介绍了喷雾干燥技术在生物治疗方面的应用,如蛋白质、可吸入粉末和活生物体的喷雾干燥,以及干燥植物提取物物理性质的改性。