通过N-杂环卡宾催化的分子内交叉安息香反应立体选择性合成具有季碳立体中心的双环叔醇。
Stereoselective synthesis of bicyclic tertiary alcohols with quaternary stereocenters via intramolecular crossed benzoin reactions catalyzed by N-heterocyclic carbenes.
作者信息
Ema Tadashi, Oue Yoshitaka, Akihara Kumiko, Miyazaki Yuki, Sakai Takashi
机构信息
Division of Chemistry and Biochemistry, Graduate School of Natural Science and Technology, Okayama University, Tsushima, Okayama 700-8530, Japan.
出版信息
Org Lett. 2009 Nov 5;11(21):4866-9. doi: 10.1021/ol9019293.
PMID:19863147
Abstract
Bicyclic tertiary alcohols 1 bearing quaternary stereocenters at the two adjacent bridgehead positions were synthesized with high stereoselectivity via the intramolecular crossed benzoin reactions catalyzed by NHC organocatalysts.
摘要
通过NHC有机催化剂催化的分子内交叉安息香反应，以高立体选择性合成了在两个相邻桥头位置带有季碳立体中心的双环叔醇1。
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