1-官能化烷基-1H-吲唑的选择性合成。
Selective synthesis of 1-functionalized-alkyl-1H-indazoles.
作者信息
Hunt Kevin W, Moreno David A, Suiter Nicole, Clark Christopher T, Kim Ganghyeok
机构信息
Array BioPharma Inc., 3200 Walnut Street, Boulder, Colorado 80301, USA.
出版信息
Org Lett. 2009 Nov 5;11(21):5054-7. doi: 10.1021/ol902050m.
PMID:19863154
Abstract
An efficient method for the selective "N1" alkylation of indazoles is described. Use of alpha-halo esters, lactones, ketones, amides, and bromoacetonitrile provides good to excellent yield of the desired N1 products.
摘要
本文描述了一种用于吲唑选择性“N1”烷基化的有效方法。使用α-卤代酯、内酯、酮、酰胺和溴乙腈可得到所需N1产物的良好至优异产率。
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