青春期前和青春期男孩急性淋巴细胞白血病（ALL）治疗后的睾丸功能

Testicular function after treatment for acute lymphoblastic leukemia (all) in prepubertal and pubertal boys.

作者信息

Krawczuk-Rybak Maryna, Solarz Elzbieta, Wysocka Jolanta, Matysiak Michal, Gadomski Artur, Kazanowska Bernarda, Sega-Pondel Dorota

机构信息

Department of Pediatric Oncology and Hematology, Medical University, Bialystok, Poland.

出版信息

Pediatr Hematol Oncol. 2009 Oct-Nov;26(7):504-14. doi: 10.1080/08880010902973665.

DOI:10.1080/08880010902973665

PMID:19863206

Abstract

Testicular function was evaluated in 59 male (27 prepubertal and 32 pubertal) survivors treated for ALL according to two different protocols. Serum inhibin B, FSH, testosterone, LH, and testicular volume were measured. In both groups the mean values of inhibin B were lower than control, whereas the other analyzed parameters were comparable. The inhibin B-to-FSH ratio was reduced as compared to the control. Testicular volume was lower than in healthy pubertal patients. The results show that treatment for ALL has a negative effect on spermatogenesis, regardless of the age at treatment and type of therapy.

摘要

根据两种不同方案对59名接受急性淋巴细胞白血病（ALL）治疗的男性幸存者（27名青春期前和32名青春期）的睾丸功能进行了评估。测量了血清抑制素B、卵泡刺激素（FSH）、睾酮、黄体生成素（LH）和睾丸体积。两组中抑制素B的平均值均低于对照组，而其他分析参数具有可比性。与对照组相比，抑制素B与FSH的比值降低。睾丸体积低于健康的青春期患者。结果表明，ALL治疗对精子发生有负面影响，无论治疗时的年龄和治疗类型如何。