Skoloudik Lukas, Vokurka Jan, Zborayova Katarina, Celakovsky Petr, Kucera Martin, Ryska Ales
Department of Otorhinolaryngology/Head & Neck Surgery, Charles University Faculty of Medicine and University Hospital, Sokolská 581, Hradec Kralove, Czech Republic.
Acta Otolaryngol. 2009 Nov;129(11):1262-5. doi: 10.3109/00016480802654398.
This study demonstrates morphological changes in the nasal mucosa as a consequence of functional changes of the nasal cavity after total laryngectomy (TLE).
Observation of the changes of the nasal mucosa in patients after TLE.
A cohort observational study contained 30 patients after TLE. These patients underwent nasal endoscopy and cytological and microbiological examination of the nasal mucosa. The control group comprised 30 patients.
In patients who underwent TLE, morphological changes occurred in the nasal mucosa. The hyperplasia of the cells in the basal zone was the most remarkable change after TLE. The difference was statistically significant (p=0.0002) in comparison with the control group. No statistically significant difference was shown in the incidence of squamous cell metaplasia. The inflammatory changes in the nasal mucosa were found in only 10% of patients after TLE; in comparison with the control group the statistically significant decrease was proven (p=0.003). The presence of bacteria in the nasal mucosa without any signs of inflammation was demonstrated in 27% of the patients who underwent TLE. That finding was not seen in the control group. The statistically significant difference was demonstrated (p=0.0046).
本研究证实全喉切除术后鼻腔功能改变导致鼻黏膜形态学变化。
观察全喉切除术后患者鼻黏膜的变化。
一项队列观察性研究纳入30例全喉切除术后患者。这些患者接受了鼻内镜检查以及鼻黏膜的细胞学和微生物学检查。对照组由30例患者组成。
接受全喉切除术的患者鼻黏膜出现形态学变化。全喉切除术后最显著的变化是基底层细胞增生。与对照组相比，差异具有统计学意义（p = 0.0002）。鳞状上皮化生的发生率无统计学显著差异。全喉切除术后仅10%的患者鼻黏膜出现炎症变化；与对照组相比，差异有统计学意义（p = 0.003）。27%接受全喉切除术的患者鼻黏膜存在细菌，但无任何炎症迹象。对照组未发现此现象。差异具有统计学意义（p = 0.0046）。
