Anna Vibeke, Woodward Mark
Deakin-Southern Health Nursing Research Centre, Melbourne, Victoria, Australia.
Womens Health (Lond). 2009 Nov;5(6):625-8. doi: 10.2217/whe.09.63.
Evaluation of: Kurth T, Schurks M, Logroscino G et al. Migraine frequency and risk of cardiovascular disease in women. Neurology 73, 581-588 (2009). There is substantial evidence that migraine with aura (MA) is associated with ischemic stroke and myocardial infarction in women. The mechanisms of this association are poorly understood. Analysis of data from the Women's Health Study, from 27,798 women over 45 years of age who were initially free of cardiovascular disease, found that women with baseline MA at a frequency of less than monthly had increased risk of major cardiovascular disease (HR: 2.28; 95% CI: 1.70-3.07) relative to women without migraine, and those who reported MA with a frequency of more than weekly had more than four-times the risk of ischemic stroke (HR: 4.25; 95% CI: 1.36-13.29) compared with those without migraine. Low numbers of outcome events in each of the frequency categories and lack of information on migraine frequency during follow-up limit the interpretation of these findings, but they suggest that frequency of migraine may be a moderating factor in the link between MA and cardiovascular disease.
库尔思·T、舒克斯·M、洛格罗西诺·G等人所著《女性偏头痛发作频率与心血管疾病风险》。《神经病学》第73卷，第581 - 588页（2009年）。有大量证据表明，有先兆偏头痛（MA）与女性缺血性中风和心肌梗死相关。这种关联的机制尚不清楚。对女性健康研究的数据进行分析，该研究涉及27,798名45岁以上且最初无心血管疾病的女性，结果发现，与无偏头痛的女性相比，基线时有先兆偏头痛且发作频率低于每月一次的女性患主要心血管疾病的风险增加（风险比：2.28；95%置信区间：1.70 - 3.07），而那些报告先兆偏头痛发作频率超过每周一次的女性，与无偏头痛的女性相比，发生缺血性中风的风险高出四倍多（风险比：4.25；95%置信区间：1.36 - 13.29）。每个发作频率类别中的结局事件数量较少，且随访期间缺乏偏头痛发作频率信息，限制了对这些发现的解读，但它们表明偏头痛发作频率可能是有先兆偏头痛与心血管疾病之间联系的一个调节因素。
