非酒精性脂肪性肝病肥胖儿童和青少年的症状和生活质量。
Symptoms and quality of life in obese children and adolescents with non-alcoholic fatty liver disease.
机构信息
Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, University of California, San Diego, La Jolla, CA 92103, USA.
出版信息
Aliment Pharmacol Ther. 2010 Feb 1;31(3):396-406. doi: 10.1111/j.1365-2036.2009.04181.x. Epub 2009 Oct 23.
BACKGROUND
Data on the quality of life (QOL) of children with non-alcoholic fatty liver disease (NAFLD) are needed to estimate the true burden of illness in children with NAFLD.
AIM
To characterize QOL and symptoms of children with NAFLD and to compare QOL in children with NAFLD with that in a sample of healthy children.
METHODS
Quality of life and symptoms were assessed in children with biopsy-proven NAFLD enrolled in the NASH Clinical Research Network. PedsQL scores were compared with scores from healthy children. For children with NAFLD, between-group comparisons were made to test associations of demography, histological severity, symptoms and QOL.
RESULTS
A total of 239 children (mean age 12.6 years) were studied. Children with NAFLD had worse total (72.8 vs. 83.8, P < 0.01), physical (77.2 vs. 87.5, P < 0.01) and psychosocial health (70.4 vs. 81.9, P < 0.01) scores compared with healthy children. QOL scores did not significantly differ by histological severity of NAFLD. Fatigue, trouble sleeping and sadness accounted for almost half of the variance in QOL scores. Impaired QOL was present in 39% of children with NAFLD.
CONCLUSIONS
Children with NAFLD have a decrement in QOL. Symptoms were a major determinant of this impairment. Interventions are needed to restore and optimize QOL in children with NAFLD.
背景
需要了解非酒精性脂肪性肝病 (NAFLD) 患儿的生活质量 (QOL) 数据，以评估 NAFLD 患儿疾病的真实负担。
目的
描述 NAFLD 患儿的 QOL 和症状，并比较 NAFLD 患儿与健康儿童的 QOL。
方法
采用 NASH 临床研究网络中经肝活检证实的 NAFLD 患儿，评估其 QOL 和症状。将 PedsQL 评分与健康儿童的评分进行比较。对 NAFLD 患儿进行组间比较，以检验人口统计学、组织学严重程度、症状与 QOL 的相关性。
结果
共纳入 239 名患儿（平均年龄 12.6 岁）。与健康儿童相比，NAFLD 患儿的总评分（72.8 对 83.8，P < 0.01）、生理健康评分（77.2 对 87.5，P < 0.01）和心理健康评分（70.4 对 81.9，P < 0.01）均较差。NAFLD 的组织学严重程度与 QOL 评分无显著相关性。疲劳、睡眠困难和悲伤占 QOL 评分的近一半。39%的 NAFLD 患儿存在 QOL 受损。
结论
NAFLD 患儿的 QOL 下降。症状是导致这种损害的主要决定因素。需要采取干预措施，恢复和优化 NAFLD 患儿的 QOL。
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