Magro Gaetano, Michal Michal, Alaggio Rita, D'Amore Emanuele
Dipartimento G.F. Ingrassia, Policlinico Universitario G. Rodolico, Anatomia Patologica, Università di Catania, Catania, Italy.
J Cutan Pathol. 2011 Jan;38(1):59-62. doi: 10.1111/j.1600-0560.2009.01460.x.
Proliferative fasciitis (PF) is a pseudosarcomatous proliferation which typically occurs in the subcutaneous tissue and fascia. Although patients are characteristically middle-aged people, occasionally PF can arise in children. Histologically, PF is characterized by a proliferation of large ganglion-like and spindle-shaped cells which, especially in childhood, may exhibit high mitotic activity, but no atypical mitoses. We report a case of PF in the dermis of a 13-year-old boy. This is the first case of PF primarily arising in the dermis. Apart from the unusual site, another intriguing finding was the presence of rare atypical mitoses, a feature which has not been previously emphasized in PF. Awareness that PF may occur in the dermis, exhibiting occasional atypical mitoses, is crucial to avoid a misdiagnosis of malignancy.
增生性筋膜炎（PF）是一种假肉瘤样增生，通常发生于皮下组织和筋膜。虽然患者以中年人为主，但PF偶尔也可发生于儿童。组织学上，PF的特征是大的神经节样细胞和梭形细胞增生，尤其是在儿童期，这些细胞可能表现出高有丝分裂活性，但无非典型有丝分裂。我们报告一例13岁男孩真皮内的PF病例。这是首例主要发生于真皮的PF病例。除了不寻常的部位外，另一个有趣的发现是存在罕见的非典型有丝分裂，这一特征在PF中以前未被强调过。认识到PF可能发生于真皮，偶尔表现出非典型有丝分裂，对于避免误诊为恶性肿瘤至关重要。
