Guillot Emmanuelle, Abe Emuri, Gautier Emilie, Annane Djillali, Alvarez Jean-Claude
Laboratoire de Pharmacologie-Toxicologie, Centre Hospitalier Universitaire Raymond Poincaré, AP-HP, Garches, France.
Therapie. 2009 Sep-Oct;64(5):325-30. doi: 10.2515/therapie/2009053. Epub 2009 Oct 30.
A 33-year-old man was hospitalized unconscious on suspicion of acute diazepam and hexobarbital intoxication, a barbiturate not marketed in France. Its quantification was developed by gas chromatography coupled with mass spectrometry detection and validated on one-hundred microL of plasma extracted by a liquid/liquid method. Hexobarbital and diazepam concentrations in initial plasma samples were at toxic levels, respectively 15 900 ng/mL and 13 800 ng/mL. Hexobarbital toxicokinetic was studied during 175 h and analysed with a non-compartmental model. Half-life value of 61,8 h was found, being much longer than already published hexobarbital half-lives (between 3.2 h and 6.9 h). The reasons of this long half-life were discussed according to metabolism and pharmacogenetic.
一名33岁男子因疑似急性地西泮和己巴比妥中毒而昏迷入院，己巴比妥是一种在法国未上市的巴比妥类药物。通过气相色谱-质谱检测对其进行定量分析，并在采用液/液萃取法提取的100微升血浆上进行了验证。初始血浆样本中的己巴比妥和地西泮浓度处于中毒水平，分别为15900纳克/毫升和13800纳克/毫升。在175小时内对己巴比妥的毒代动力学进行了研究，并采用非房室模型进行分析。发现其半衰期值为61.8小时，远长于已发表的己巴比妥半衰期（3.2小时至6.9小时之间）。根据代谢和药物遗传学对这种长半衰期的原因进行了讨论。
