Khachman Dalia, Gandia Peggy, Sallerin François, Mailly Nicolas
Laboratoire de Pharmacocinétique et Toxicologie Clinique, Hôpital Purpan, Institut Fédératif de Biologie, Toulouse, France.
Therapie. 2009 Sep-Oct;64(5):331-9. doi: 10.2515/therapie/2009040. Epub 2009 Oct 30.
Diagnostic and interventional radiology of patients is nowadays crucial with increasing requirement for iodinated contrast agents infusion. Besides adverse reactions after administration of the iodinated contrast agents due to their toxicity, immediate hypersensitivity reactions and reactions resembling delayed hypersensitivity appearing from 1 hour to several days later, have been reported. Patients at high risk to develop such adverse events have to be detected on the basis of their risk factors in order to prevent or limit serious outcomes. Previous reactions to contrast media, asthma, atopy and cardiovascular disorders are risk factors for anaphylactic or anaphylactoid reactions. Female gender, age and beta-blockers increase the severity. This article aims to summarize the risk of allergic reactions related to the use of iodinated contrast agents and to suggest a way for diagnosis, treatment and prevention according to each clinical situation.
如今，随着对碘化造影剂输注需求的增加，患者的诊断性和介入性放射学变得至关重要。除了由于碘化造影剂的毒性导致给药后出现不良反应外，还报告了立即发生的过敏反应以及在1小时至数天后出现的类似迟发性过敏反应。必须根据高危患者的危险因素来检测他们，以预防或限制严重后果。既往对造影剂的反应、哮喘、特应性和心血管疾病是过敏或类过敏反应的危险因素。女性、年龄和β受体阻滞剂会增加反应的严重程度。本文旨在总结与使用碘化造影剂相关的过敏反应风险，并根据每种临床情况提出诊断、治疗和预防方法。
