低发生率红细胞抗原Wra：遗传学研究

The low-incidence red cell antigen Wra: genetic studies.

作者信息

Lewis M, Kaita H, Philipps S, McAlpine P J

机构信息

Department of Pediatrics, University of Manitoba, Winnipeg, Canada.

出版信息

Transfusion. 1991 Jan;31(1):47-51. doi: 10.1046/j.1537-2995.1991.31191096185.x.

DOI:10.1046/j.1537-2995.1991.31191096185.x

PMID:1986464

Abstract

Studies of 91 individuals in three families allowed a genetic-linkage analysis of the gene governing the production of the low-incidence red cell antigen Wra and provided evidence that Wra is not a member of the Scianna, Landsteiner-Wiener, Chido/Rodgers, or XK blood group systems, and that the "WR" locus is excluded from autosomal sites or regions 1p34-p22.1, 1p21-q23, 1q32, 2p25, 3q21, 4q28-q32, 6p24-q12, 9q34.1-q34.2, 13q14.1-q14.2, 14q24.3-q32.1, 14q32.33, 16p13, 16q22.1, and 21q21-q22.1. "WR" is also excluded from within specified genetic distances of chromosomes 8 (GPT), 18 (JK), 19 (C3), 20 (ADA), and 22 (P1) loci, which brings its exclusion to approximately 10 percent (320cM) of the total genetic map of the genome. The possibility that "WR" is pseudoautosomal is deemed to be highly unlikely.

摘要

对三个家族中91人的研究使得对控制低发生率红细胞抗原Wra产生的基因进行了遗传连锁分析，并提供了证据表明Wra不是斯恰纳、兰德施泰纳-维纳、奇多/罗杰斯或XK血型系统的成员，并且“WR”基因座被排除在常染色体位点或区域1p34 - p22.1、1p21 - q23、1q32、2p25、3q21、4q28 - q32、6p24 - q12、9q34.1 - q34.2、13q14.1 - q14.2、14q24.3 - q32.1、14q32.33、16p13、16q22.1和21q21 - q22.1之外。“WR”也被排除在染色体8（GPT）、18（JK）、19（C3）、20（ADA）和22（P1）基因座的特定遗传距离之内，这使得其被排除的范围达到基因组总遗传图谱的约10%（320厘摩）。“WR”为假常染色体的可能性被认为极不可能。