Ashani Y, Shapira S, Levy D, Wolfe A D, Doctor B P, Raveh L
Israel Institute for Biological Research, Ness-Ziona.
Biochem Pharmacol. 1991 Jan 1;41(1):37-41. doi: 10.1016/0006-2952(91)90008-s.
Human butyrylcholinesterase (BChE, EC 3.1.1.8) or acetylcholinesterase (AChE, EC 3.1.1.7) from fetal bovine serum (FBS), administered i.v. in mice, sequestered at approximately 1:1 stoichiometry the highly toxic anti-ChE organophosphate, 1,2,2-trimethylpropyl methyl-fluorophosphonate (soman). A quantitative linear correlation was demonstrated between blood-ChE levels and the protection conferred by exogeneously administered ChE. Results presented here demonstrate that either human BChE or FBS-AChE is an effective prophylactic measure sufficient to protect mice from multiple LD50S of soman without the administration of post-treatment supportive drugs.
静脉注射给予小鼠胎牛血清（FBS）中的人丁酰胆碱酯酶（BChE，EC 3.1.1.8）或乙酰胆碱酯酶（AChE，EC 3.1.1.7），其以约1:1的化学计量比隔离剧毒的抗胆碱酯酶有机磷酸酯1,2,2-三甲基丙基甲基氟膦酸酯（梭曼）。在外源给予胆碱酯酶所提供的保护与血胆碱酯酶水平之间证明了定量线性相关性。此处给出的结果表明，人BChE或FBS-AChE均是一种有效的预防措施，足以保护小鼠免受梭曼多个半数致死剂量的影响，而无需给予治疗后支持药物。
