Pathological Laboratory of The Presbyterian Hospital, New York.
J Exp Med. 1912 Jul 1;16(1):1-16. doi: 10.1084/jem.16.1.1.
Although the results of this study have been of a negative character, the conclusions that may be drawn from it have an important bearing on the true anatomical character of the islands. 1. Neither inanition nor the prolonged injection of secretin has any noteworthy effect upon the number, size, or structure of the islands of Langerhans in the dog's pancreas. 2. The islands of Langerhans in the guinea pig's pancreas are in no way altered in phlorizin diabetes. 3. The islands of Langerhans are not formed out of exhausted or degenerated acini, but develop from the ducts or acini with which they are often in direct continuity.
尽管这项研究的结果是负面的，但从中得出的结论对这些岛屿的真实解剖特征有着重要的影响。1. 在狗的胰腺中，无论是饥饿还是长期注射促胰液素，对胰岛的数量、大小或结构都没有显著影响。2. 在梓醇糖尿病中，豚鼠胰腺的胰岛没有任何变化。3. 胰岛不是由耗尽或退化的腺泡形成的，而是由它们通常直接连续的导管或腺泡发育而来。
