Department of Pathology, College of Physicians and Surgeons, Columbia University, New York.
J Exp Med. 1912 Oct 1;16(4):512-26. doi: 10.1084/jem.16.4.512.
The liver of the embryo chick during the first two weeks of development contains an abundance of isotropic fatty globules which represent a mixture of lipoids in which phosphorized fats predominate. During the third week of incubation the fatty globules in the liver change their physical and chemical characters. They become anisotropic and exhibit the reactions and properties of esters of cholesterol. The phosphorized fats gradually disappear from the liver during the third week. The phosphoric acid utilized by the embryo chick in calcification is derived from phosphorized fats. It is suggested that the phosphorized fats are split in the liver, the glycerophosphoric acid portion being liberated for calcification, while the free fatty acids are esterfied by cholesterol. A review of chemical analyses of aortic atherosclerosis and calcification made by others, and a comparison of the conditions in atherosclerosis with those of the developing chick liver, suggest that pathological calcification results from a splitting in situ of phosphorized fats with subsequent formation of calcium salts, as suggested by Baldauf.
胚胎鸡的肝脏在发育的头两周含有丰富的各向同性脂肪球，这些脂肪球代表了以磷酯为主的脂类混合物。在孵化的第三周，肝脏中的脂肪球改变了它们的物理和化学性质。它们变得各向异性，并表现出胆固醇酯的反应和性质。在第三周期间，肝脏中的磷酯逐渐消失。胚胎鸡在钙化过程中利用的磷酸来自磷酯。有人认为，磷酯在肝脏中被分解，甘油磷酸部分被释放用于钙化，而游离脂肪酸则被胆固醇酯化。对其他人对主动脉粥样硬化和钙化的化学分析的回顾，以及对粥样硬化条件与发育中的鸡肝条件的比较，表明病理性钙化是由于磷酯的原位分解，随后形成钙盐，正如 Baldauf 所建议的那样。
