慢性感染变形性关节炎和变形性关节炎中的补体固定试验。

COMPLEMENT FIXATION TESTS IN CHRONIC INFECTIVE DEFORMING ARTHRITIS AND ARTHRITIS DEFORMANS.

Department of Clinical Pathology of Cornell University Medical College, and The Second Medical Division of Bellevue Hospital, New York.

J Exp Med. 1914 Jul 1;20(1):52-71. doi: 10.1084/jem.20.1.52.

Abstract

From a comparison of the results with arthritis deformans recorded in tables III, IV, and VI, and with the control cases recorded in table VII, one is justified in concluding that Streptococcus viridans is an infectious agent and excites the production of a complement-fixing substance (fixateur) in the organism in cases of arthritis deformans, and, therefore, Streptococcus viridans is the probable causative agent of the disease in many cases of arthritis deformans. Probably 40 per cent. and more of cases of arthritis deformans should be considered as chronic infective deforming arthritis. 2. Rarely the clinical manifestations of arthritis deformans may be due to gonococcus infection. 3. The serum from one case may react positively to two different organisms, most frequently to Streptococcus viridans and to gonococcus, when the reaction to the former should be considered the indicator of the causative agent, since with the latter infection is often latent in the genito-urinary tract. Incidence of gonococcus infection is high and the clinical manifestations of arthritis deformans are rarely produced by gonococcus infection.

摘要

通过将 III、IV 和 VI 表中记录的关节炎变形的结果与 VII 表中记录的对照病例进行比较，可以得出结论，草绿色链球菌是一种感染因子，在关节炎变形病例中激发了补体固定物质（fixateur）的产生，因此，草绿色链球菌是许多关节炎变形病例中疾病的可能致病因子。大约 40%及更多的关节炎变形病例应被视为慢性感染性变形关节炎。
关节炎变形的临床表现很少可能是由淋球菌感染引起的。
一例血清可能对两种不同的生物体呈阳性反应，最常见的是草绿色链球菌和淋球菌，而前者的反应应被视为致病因子的指标，因为后者感染在生殖道中常常是潜伏的。淋球菌感染的发生率很高，而关节炎变形的临床表现很少由淋球菌感染引起。