肾小球肾炎研究：二、用白喉毒素和大肠杆菌产生的一种急性肾小球肾炎。
STUDIES IN GLOMERULONEPHRITIS : II. A FORM OF ACUTE GLOMERULONEPHRITIS PRODUCED WITH DIPHTHERIA TOXIN AND BACILLUS COLI.
机构信息
Laboratory of Pediatrics of Stanford University Medical School, San Francisco.
出版信息
J Exp Med. 1917 Aug 1;26(2):153-62. doi: 10.1084/jem.26.2.153.
Abstract
- Rabbits in which a mild grade of glomerular damage has been produced by small doses of diphtheria toxin develop a severe glomerulonephritis corresponding to the extracapillary form described by Volhard and Fahr after inoculations with sublethal quantities of Bacillus coli. 2. Similar, though not completely identical lesions are produced when diphtheria toxin is followed by intravenous injections of Vaughan's split protein (poisonous part) of Bacillus coli. 3. The inference is drawn that under the experimental conditions described Bacillus coli undergoes bacteriolysis and produces glomerular lesions through the toxic groups contained within its protein molecule.
摘要
用小剂量白喉毒素使家兔产生轻度肾小球损害，可引起严重的肾小球肾炎，类似于用小致死量的大肠杆菌接种后，由 Volhard 和 Fahr 所描述的毛细血管外肾小球肾炎。
当白喉毒素后紧接着静脉内注射 Vaughan 的大肠杆菌分裂蛋白（有毒部分）时，可产生类似的、但不完全相同的损害。
推断在所述的实验条件下，大肠杆菌发生菌裂，并通过其蛋白质分子内所含的毒性基团而产生肾小球损害。
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