Laboratories of The Rockefeller Institute for Medical Research.
J Exp Med. 1924 Apr 30;39(5):625-30. doi: 10.1084/jem.39.5.625.
In this communication we have described a strain of the virus of poliomyelitis derived from a rapidly fatal human case, which exhibits mild degrees of infective power and marked degrees of protective effect for the monkey. While Macacus rhesus displays perceptible differences in suceptibility to the attenuated virus, nearly all individuals respond to the inoculation and none succumbs to the infection induced. As compared with previously described examples of experimental poliomyelitis, the modified disease described in this paper is distinguished by its relatively benign nature and its tendency to end in recovery rather than, as with the earlier observed instances, in death.
在本通讯中，我们描述了一株脊髓灰质炎病毒，源自一例迅速致命的人类病例，该病毒表现出轻微的感染能力和显著的保护猴子的效果。虽然恒河猴对减毒病毒的敏感性存在明显差异，但几乎所有个体对接种均有反应，没有个体因感染而死亡。与先前描述的实验性脊髓灰质炎病例相比，本文中描述的改良疾病的特点是其性质相对良性，且倾向于恢复而不是像早期观察到的那样导致死亡。
