Hospital of The Rockefeller Institute for Medical Research.
J Exp Med. 1925 Mar 31;41(4):551-60. doi: 10.1084/jem.41.4.551.
Hemoglobin is oxidized to methemoglobin by products formed during the oxidation of a number of different substances. With some of these substances, both oxygen consumption and hemoglobin oxidation are accelerated by thermolabile constituents of pneumococci; with others of the easily oxidized substances, neither reaction seems to be influenced by the presence of the bacterial substances. The same substances which in the presence of air induce the oxidation of hemoglobin bring about the reverse reaction if molecular oxygen is excluded.
血红蛋白可被多种不同物质氧化过程中形成的产物氧化为高铁血红蛋白。对于其中一些物质,氧气消耗和血红蛋白氧化都可被肺炎球菌的热敏成分加速;而对于其他易于氧化的物质,这两种反应似乎都不受细菌物质的影响。在有空气存在的情况下能诱导血红蛋白氧化的相同物质,如果排除了分子氧,就会引起相反的反应。