Laboratories of The Rockefeller Institute for Medical Research.
J Exp Med. 1926 Jun 30;44(1):1-10. doi: 10.1084/jem.44.1.1.
An invisible, filter-passing virus, pathogenic for the guinea pig, and capable of cultivation on special media for at least seven generations, has been isolated from a tick of the species Dermacentor andersoni. One of two monkeys (Macacus rhesus) inoculated became infected, and in one rabbit the result was negative. The virus has been transmitted from infected guinea pigs to ticks as also in one instance by tick feeding from an infected tick to a guinea pig The presence of the virus in the tick is more easily demonstrated by the inoculation of guinea pigs with a suspension of the tick viscera. Continuous high fever (104.5-106.5 degrees F.) and enlargement of the spleen are the chief symptoms of the infection in guinea pigs. After the febrile attack the guinea pigs are not susceptible to reinoculation with the cultured virus but are subject to infection with the virus of spotted fever, and vice versa.
从安氏革蜱中分离到一种对豚鼠致病的、可滤过的、无形的病毒，它能用特殊培养基至少连续传代培养 7 代。接种的两只猴子中的 1 只被感染，1 只兔的结果为阴性。已证实该病毒可经感染豚鼠传播给蜱，也可经蜱吸血而传播。用蜱的内脏悬液接种豚鼠，更易证明蜱体内存在这种病毒。感染豚鼠的主要症状是持续高热（104.5-106.5°F）和脾脏肿大。发热后豚鼠对培养的病毒不再易感，但易感染落矶山斑点热的病毒，反之亦然。
