Saranac Lake Laboratory for the Study of Tuberculosis, Saranac Lake, and the Laboratory of the New York State Hospital for Incipient Tuberculosis, Ray Brook.
J Exp Med. 1927 Feb 28;45(3):553-60. doi: 10.1084/jem.45.3.553.
These observations have brought out three facts which may be stated briefly as follows. 1. An acute respiratory epidemic was incited by mucoid strains of Bact. lepisepticum of moderate and uniform virulence. 2. The epidemic was brought about not by an alteration in the virulence of the prevailing strains of Bact. lepisepticum but by a sudden distribution of virulent organisms among a susceptible population hitherto unexposed. 3. Individuals in this population showed different degrees of resistance to the infecting bacillus; some died from pneumonia and septicemia, while others localized the infection to the nasal passages. The significance of these facts has been discussed at length elsewhere (4).
这些观察结果揭示了三个事实，可以简要地陈述如下。1. 一种黏液性的中等且均匀毒力的败血性巴斯德氏菌菌株引起了急性呼吸道传染病。2. 这种传染病不是由流行的巴斯德氏菌菌株毒力的改变引起的，而是由于具有强烈毒性的生物体在易感人群中的突然传播，这些人群以前从未接触过这些生物体。3. 该人群中的个体对感染性杆菌表现出不同程度的抵抗力；一些人死于肺炎和败血病，而另一些人则将感染局限在鼻腔。这些事实的意义已在其他地方进行了详细讨论（4）。
