溶血链球菌抗原复合体：V. 与型特异性物质的过敏反应。
THE ANTIGENIC COMPLEX OF STREPTOCOCCUS HAEMOLYTICUS : V. ANAPHYLAXIS WITH THE TYPE-SPECIFIC SUBSTANCE.
机构信息
Hospital of The Rockefeller Institute for Medical Research.
出版信息
J Exp Med. 1928 May 31;47(6):857-75. doi: 10.1084/jem.47.6.857.
Abstract
- Type-specific anaphylactic shock was produced with HCI extracts of Streptococcus haemolyticus in guinea pigs passively sensitized with antibacterial sera. 2. With occasional sera and certain HCl extracts, type-specific shock was not produced unless the serum was first absorbed with heterologous bacteria or unless the guinea pigs were desensitized with heterologous extracts before testing with the homologous extract. The findings indicated that this was due to the presence of the non-type-specific substance which has been provisionally designated as Y. 3. Tryptic digestion destroyed the ability of HCI extracts containing the type-specific M substance and the non-type-specific Y substance to produce anaphylactic shock in passively sensitized guinea pigs. 4. Active sensitization was not accomplished with the type-specific M. It seems probable, therefore, that this substance is a hapten, reacting with antibodies but not stimulating their production after separation from the bacterial cell.
摘要
用被动敏化豚鼠的抗菌血清的 HCI 提取物产生了特异性过敏休克链球菌。
偶尔会出现一些血清和特定的 HCl 提取物，如果血清不首先用异源细菌吸收，或者在用同源提取物测试之前，豚鼠不先用异源提取物脱敏，就不会产生特异性休克。这些发现表明，这是由于存在非特异性物质，该物质被临时命名为 Y。
胰蛋白酶消化破坏了含有特异性 M 物质和非特异性 Y 物质的 HCl 提取物在被动敏化豚鼠中引起过敏休克的能力。
特异性 M 物质不能完成主动敏化。因此，这种物质很可能是一种半抗原，与抗体反应，但与细菌细胞分离后不会刺激其产生。
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