溶血链球菌抗原复合物：IV. 两种非特异性片段的过敏反应。

THE ANTIGENIC COMPLEX OF STREPTOCOCCUS HAEMOLYTICUS : IV. ANAPHYLAXIS WITH TWO NON-TYPE-SPECIFIC FRACTIONS.

机构信息

Hospital of The Rockefeller Institute for Medical Research.

出版信息

J Exp Med. 1928 May 31;47(6):843-55. doi: 10.1084/jem.47.6.843.

DOI:10.1084/jem.47.6.843

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2131440/

Abstract

The anaphylactic reactions of two non-type-specific fractions of hemolytic streptococcus extracts parallel the precipitin reactions. The nucleoprotein, P, is a true antigen, in that it stimulates antibody production in rabbits, as shown before, and produces anaphylactic shock in guinea pigs actively as well as passively. The probable carbohydrate, C, on the other hand, does not induce antibody formation in rabbits, so far as known at present, but does produce typical anaphylactic shock in guinea pigs passively sensitized with antibacterial serum provided the serum shows a high titer of C precipitins. This is an instance of a hapten, probably carbohydrate in nature, causing anaphylactic shock in passively sensitized guinea pigs.

摘要

两种非特异性溶血链球菌提取物的过敏反应与沉淀反应平行。核蛋白 P 是一种真正的抗原，正如之前所展示的，它能刺激兔子产生抗体，并能主动和被动地引起豚鼠的过敏休克。另一方面，可能的碳水化合物 C 迄今为止还不能诱导兔子产生抗体，但在使用抗菌血清被动致敏的豚鼠中会产生典型的过敏休克，如果血清中含有高滴度的 C 沉淀素的话。这是一种半抗原（可能是碳水化合物）引起被动致敏豚鼠过敏休克的实例。

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