Hospital of The Rockefeller Institute for Medical Research.
J Exp Med. 1933 Jun 30;58(1):39-53. doi: 10.1084/jem.58.1.39.
No evidence was found to support the idea that vaccine virus placed in the cisterna magna is capable of producing an acute disseminated encephalomyelitis with perivascular demyelination either in normal or in partially immune monkeys. A testicular extract (Reynals' factor) did not induce vaccine virus to cause an acute disseminated encephalomyelitis in monkeys. Repeated intramuscular injections of brain extracts and brain emulsions into eight monkeys were followed in two instances by an inflammatory reaction, accompanied by demyelination, in the central nervous system. The exact relation of the injections to the disease of the nervous system is not clear. The combined action of vaccine virus and an emulsion of fresh rabbit brain did not lead to the production of an acute disseminated encephalomyelitis in monkeys that had received repeated intramuscular injections of emulsions and alcohol-ether extracts of normal rabbit brains.
没有证据表明,将疫苗病毒置于小脑延髓池内能够在正常或部分免疫的猴子中引起伴血管周围脱髓鞘的急性播散性脑脊髓炎。睾丸提取物(雷纳尔斯因子)不能诱导疫苗病毒引起猴子的急性播散性脑脊髓炎。将脑提取物和脑乳剂重复肌肉注射入 8 只猴子中,有 2 例在中枢神经系统中出现炎症反应,伴有脱髓鞘。注射与神经系统疾病的确切关系尚不清楚。在已接受正常兔脑乳剂和酒精乙醚提取物重复肌肉注射的猴子中,疫苗病毒和新鲜兔脑乳剂的联合作用并未导致急性播散性脑脊髓炎的发生。