KABAT E A, WOLF A, BEZER A E
J Exp Med. 1948 Oct 1;88(4):417-26. doi: 10.1084/jem.88.4.417.
The factor in brain tissue which induces acute disseminated encephalomyelitis, when injected into rhesus monkeys as an emulsion with adjuvants, has been found in human, monkey, rabbit, and chicken brain but is absent from frog and fish brain. It is unaffected by fixation of the brain in formalin, by boiling, and by treatment with ultrasound. It is present in the spinal cord of 3 day old rabbits but does not appear in the rabbit cerebrum until about the 12th day of life; in this respect it parallels the laying down of myelin. Attempts to produce the encephalomyelitis passively with large quantities of serum or of cell exudates, and suspensions of cells from spleen and lymph node from monkeys with encephalomyelitis, were unsuccessful.
当与佐剂制成乳剂注入恒河猴体内时,可诱发急性播散性脑脊髓炎的脑组织因子,已在人、猴、兔和鸡的脑中发现,但蛙和鱼的脑中没有。它不受脑在福尔马林中固定、煮沸以及超声处理的影响。它存在于3日龄兔的脊髓中,但直到出生后约第12天才出现在兔大脑中;在这方面它与髓磷脂的形成过程相似。试图用大量血清、细胞渗出液以及患脑脊髓炎猴子的脾和淋巴结细胞悬液被动诱发脑脊髓炎均未成功。